Treatment of refractory substance-induced psychosis in adolescent males with a genetic predisposition to mental illness

  title={Treatment of refractory substance-induced psychosis in adolescent males with a genetic predisposition to mental illness},
  author={Mariam Rahmani and Sean Paul and Mathew Nguyen},
  journal={International Journal of Adolescent Medicine and Health},
  pages={297 - 301}
Abstract This article presents two cases of adolescent males who were admitted to our inpatient psychiatric unit with a psychotic, disorganized presentation. Both males had a genetic vulnerability to mental illness and reported significant substance use. Their symptoms were refractory to treatment and required the use of clozapine. Both patients experienced significant side effects, which limited the maximum daily dose of clozapine. However, they responded to a dose that was much lower than… 

Substance-Induced Psychoses: An Updated Literature Review

The theory that psychosis due to substance abuse is commonly observed in clinical practice is supported, and the propensity to develop psychosis seems to be a function of the severity of use and addiction.

Distinguishing schizophrenia from posttraumatic stress disorder with psychosis

A large genome-wide association study (GWAS) has identified a collection of genes associated with PTSD, and these genes overlap with those identified as increasing the risk of developing schizophrenia.

Psychosis and synthetic cannabinoids

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[Can cannabis use increase the risk for schizophrenic psychoses?].

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Cannabis use and risk of psychotic or affective mental health outcomes: a systematic review

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The Incidence of First-Episode Schizophrenia-Spectrum Psychosis in Adolescents and Young Adults in Montreal: An Estimate from an Administrative Claims Database

Clinical samples obtained from psychiatric services are unlikely to capture all treatment-seeking patients, and epidemiologic surveys have resource-intensive constraints, making this approach challenging for rare forms of psychopathology; therefore, population-based administrative data may be a useful tool for studying the frequency of psychotic disorders.

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The data suggest that clozapine in the present population of newly admitted, acutely psychotic schizophrenic individuals, and in the doses employed, was more effective in overall improvement response, discharge rate, and ameliorating discrete symptoms across the different objective rating scales used than was chlorpromazine (Thorazine) hydrochloride.

Sex difference in age at onset of schizophrenia.

  • A. Loranger
  • Psychology, Medicine
    Archives of general psychiatry
  • 1984
The age at onset of schizophrenia was determined in 100 male and 100 female patients who unequivocally met DSM-III criteria for the illness and the sex difference is not readily apparent, but it could be a valuable clue to some of the causes of schizophrenia.

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Self reported cannabis use is associated with an increased risk of subsequently developing schizophrenia, consistent with a causal relation This association is not explained by sociability personality traits, or by use of amphetamines or other drugs Self medication with cannabis is an unlikely explanation for the association observed.