Treatment of refractory cutaneous lupus erythematosus.

  title={Treatment of refractory cutaneous lupus erythematosus.},
  author={G F Duna and Joseph M. Cash},
  journal={Rheumatic diseases clinics of North America},
  volume={21 1},
Photoprotection, topical steroids, and hydroxychloroquine are the mainstays of therapy of cutaneous LE. In severe and/or refractory disease, antimalarials remain the drugs of choice, and multiple induction and combination strategies can be employed to achieve optimal results with minimal toxicity. Retinoids, dapsone, clofazimine, and thalidomide are effective but more toxic alternatives. Their use dictates frequent and careful monitoring. Retinoids and thalidomide are teratogenic, and… CONTINUE READING