Treatment of refractory complex partial seizures: role of vigabatrin

@inproceedings{Waterhouse2009TreatmentOR,
  title={Treatment of refractory complex partial seizures: role of vigabatrin},
  author={Elizabeth J. Waterhouse and Kimberly Nicole Mims and S. N. Narayan Gowda},
  booktitle={Neuropsychiatric disease and treatment},
  year={2009}
}
Vigabatrin (VGB) is an antiepileptic drug that was designed to inhibit GABA-transaminase, and increase levels of gamma-amino-butyric acid (GABA), a major inhibitory neurotransmitter in the brain. VGB has demonstrated efficacy as an adjunctive antiepileptic drug for refractory complex partial seizures (CPS) and for infantile spasms (IS). This review focuses on its use for complex partial seizures. Although VGB is well tolerated, there have been significant safety concerns about intramyelinic… CONTINUE READING

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