Treatment of refractory autoimmune diseases with autologous stem cell transplantation: focus on juvenile idiopathic arthritis

Abstract

Summary:Autologous stem cell transplantation (ASCT) can be performed in a variety of refractory autoimmune diseases. A retrospective multicenter analysis is presented to evaluate safety and efficacy of ASCT for refractory juvenile idiopathic arthritis. In all, 18 of the 34 patients (53%) with a follow-up of 12 to 60 months achieved a drug-free complete remission. There were three cases (9%) of transplant-related mortality and two cases of disease-related mortality (6%). Infectious complications were seen frequently. We propose adjustments in future protocols to reduce this mortality in this high-risk patient group.

DOI: 10.1038/sj.bmt.1704840

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Cite this paper

@article{Wulffraat2005TreatmentOR, title={Treatment of refractory autoimmune diseases with autologous stem cell transplantation: focus on juvenile idiopathic arthritis}, author={N. M. Wulffraat and Bas J Vastert and Alan Tyndall}, journal={Bone Marrow Transplantation}, year={2005}, volume={35}, pages={S27-S29} }