Treatment of rats with the peroxisome proliferator ciprofibrate results in increased liver NF-kappaB activity.

@article{Li1996TreatmentOR,
  title={Treatment of rats with the peroxisome proliferator ciprofibrate results in increased liver NF-kappaB activity.},
  author={Yanzhang Li and Lai K Leung and Howard Perry Glauert and B. Spear},
  journal={Carcinogenesis},
  year={1996},
  volume={17 11},
  pages={2305-9}
}
Nuclear factor kappaB (NF-kappaB) is an important stress-induced transcription factor in many cell types, including hepatocytes. Previous studies have shown that reactive oxygen species, including hydrogen peroxide, are potent activators of NF-kappaB. Peroxisome proliferators are a group of rodent chemical carcinogens that have been proposed to act by increasing reactive oxygen in the liver. These results led us to consider whether peroxisome proliferators would increase NF-kappaB activity in… CONTINUE READING