Treatment of prostate carcinoma with (galectin-3)-targeted HPMA copolymer-(G3-C12)-5-Fluorouracil conjugates.

  title={Treatment of prostate carcinoma with (galectin-3)-targeted HPMA copolymer-(G3-C12)-5-Fluorouracil conjugates.},
  author={Yang Yang and Zhou Zhou and Shuang He and Tingting Fan and Yun Yun Jin and Xi Zhu and Chunhui Chen and Zhirong Zhang and Yuan Huang},
  volume={33 7},
Galectin-3 (Gal-3), over-expressed on a variety of human tumor cells, is a potential binding site for targeted metastatic prostate cancer therapy. The aim of this study was to develop a G3-C12-mediated drug delivery system based on N-(2-hydroxypropyl) methacrylamide (HPMA) copolymers targeting to Gal-3-expressed human PC-3 prostate carcinoma cells. 5-Fluorouracil (5-Fu), an anti-tumor agent, was selected as a model drug. G3-C12, a binding peptide, which specifically binds to the carbohydrate… CONTINUE READING
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Synthesis and characterization of HPMA copolymere5-FU conjugates

  • F Yuan, F Chen, QY Xiang, X Qin, ZR Zhang, Y. Huang
  • Chin Chem Lett 2008;19:
  • 2008
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