Treatment of progressive or recurrent pediatric malignant supratentorial brain tumors with herpes simplex virus thymidine kinase gene vector-producer cells followed by intravenous ganciclovir administration.

@article{Packer2000TreatmentOP,
  title={Treatment of progressive or recurrent pediatric malignant supratentorial brain tumors with herpes simplex virus thymidine kinase gene vector-producer cells followed by intravenous ganciclovir administration.},
  author={Roger J. Packer and Corey Raffel and Judith G Villablanca and J C Tonn and Stefan E. G. Burdach and K M Burger and Debbie Lafond and J G Mccomb and Phillip H. Cogen and Gilbert Vezina and Leonard P. Kapcala},
  journal={Journal of neurosurgery},
  year={2000},
  volume={92 2},
  pages={249-54}
}
OBJECT The outcome for children with recurrent malignant brain tumors is poor. The majority of patients die of progressive disease within months of relapse, and other therapeutic options are needed. The goal of this Phase I study was to evaluate the safety of in vivo suicide gene therapy in 12 children with recurrent, malignant, supratentorial brain tumors. METHODS After optimal repeated tumor resection, multiple injections of murine vector-producing cells shedding murine replication… CONTINUE READING
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