Treatment of primary hyperhidrosis with oral anticholinergic medications: a systematic review

  title={Treatment of primary hyperhidrosis with oral anticholinergic medications: a systematic review},
  author={Lucinda Cruddas and D. Baker},
  journal={Journal of the European Academy of Dermatology and Venereology},
  • L. Cruddas, D. Baker
  • Published 1 June 2017
  • Medicine, Psychology
  • Journal of the European Academy of Dermatology and Venereology
Primary hyperhidrosis is a condition characterized by excessive sweating. Patients are treated off‐license with oral anticholinergic medications and report adverse events associated with systemic anticholinergic interactions. This review assesses clinical evidence of efficacy, impact on quality of life and adverse events associated with oral anticholinergic therapy for primary hyperhidrosis. PRISMA guidelines were implemented to complete a systematic review (PROSPERO:CRD42016036326). MEDLINE… 

The treatment of palmar hyperhidrosis - a systematic review.

  • Hannah Chudry
  • Medicine, Psychology
    International journal of dermatology
  • 2021
There are few good quality studies evaluating the treatment of primary PH, and the interventions reviewed significantly improve the symptoms of PH.

Safety of available and emerging drug therapies for hyperhidrosis

Efficacy and safety data on aluminum salts, anticholinergic drugs for topical or systemic application, and on intradermal botulinum toxin injections used to treat hyperhidrosis are critically evaluated, including data from clinical trials with focus on possible side effects and long-term complications in dispute.

The pharmacological treatment and management of hyperhidrosis

The authors report on, in this narrative review, the emerging data from the literature focusing on the pharmacological treatments to draw up a drug treatment flow chart for patients with idiopathic hyperhidrosis, taking into consideration specific differences among axillary, palmoplantar, and craniofacialhyperhidrosis.

Progress and lack of progress in hyperhidrosis research 2015–2020. A concise systematic review

In a 5‐year‐old systematic review, it was concluded that there was moderate‐quality evidence to support the use of botulinum toxin for axillary hyperhidrosis and it was advocated to conduct a trial comparing BTX and iontophoresis for palmarhyperhidrosis.

Survival study of treatment adherence by patients given oral glycopyrrolate for hyperhidrosis following treatment failure with oral oxybutynin

The main variables associated with treatment adherence by patients receiving OGly, for whom previous treatment with OOx had failed, were identified and provided valuable insights into the outcomes achieved when OGly is used to treat hyperhidrosis.

Cost-effectiveness of topical glycopyrronium tosylate for the treatment of primary axillary hyperhidrosis

Glycopyrronium tosylate as first-line topical therapy compared to topical aluminum chloride from a United States commercial perspective may be cost-effective relative to prescription aluminum chloride at commonly accepted willingness to pay thresholds.

Management Strategies Of Palmar Hyperhidrosis: Challenges And Solutions

This review will provide an update on current and emerging concepts of management for excessive hand sweating to help clinicians optimize therapeutic decision-making.

Oxybutynin in primary hyperhidrosis: A long‐term real‐life study

This real life study suggests that oxybutynin is effective and safe for treatment of hyperhidrosis, both in children and adults, with mild and tolerable side effects, with significant improvement in HDSS.

Stepwise treatment of primary focal hyperhidrosis with aluminum chloride hexahydrate lotion (20%) and oral glycopyrrolate: a retrospective study from a tertiary care center

Addition of OGP to topical ACH increases the treatment efficacy in patients with primary focal hyperhidrosis and increasing the glycopyrrolate dose augments the response further.

HYPERHIDROSIS TABLE 2 Select Medications That May Cause Secondary Hyperhidrosis Antidepressants

The Hyperhidrosis Disease Severity Scale is a validated survey used to grade the tolerability of sweating and its impact on quality of life and Oral anticholinergics are useful adjuncts in severe cases of hyperhidrosis when other treatments fail.



Systemic therapy for primary hyperhidrosis: a retrospective study of 59 patients treated with glycopyrrolate or clonidine.

  • H. Walling
  • Medicine
    Journal of the American Academy of Dermatology
  • 2012

Oral glycopyrrolate as second-line treatment for primary pediatric hyperhidrosis.

Efficacy of Glycopyrrolate in Primary Hyperhidrosis Patients

Glycopyrrolate is an effective initial method of treating primary hyperhidrosis that, reduces anxiety and improve patients' quality of life.

Primary focal hyperhidrosis: current treatment options and a step‐by‐step approach

  • I. HoorensK. Ongenae
  • Medicine
    Journal of the European Academy of Dermatology and Venereology : JEADV
  • 2012
The challenge for the dermatologist remains to evaluate the severity of hyperhidrosis to achieve the best therapeutic outcome, this can be done most effectively using the Hyperhidrosis Disease Severity Scale (HDSS).

An alternative to treat palmar hyperhidrosis: use of oxybutynin

The use of oxybutynin is an alternative as the first step in the treatment of palmar hyperhidrosis, given that it presents good results and improves QOL.

Primary hyperhidrosis increases the risk of cutaneous infection: a case-control study of 387 patients.

  • H. Walling
  • Medicine
    Journal of the American Academy of Dermatology
  • 2009

Treatment of uncommon sites of focal primary hyperhidrosis: experience with pharmacological therapy using oxybutynin

Oxybutynin is effective for treating bothersome hyperhidrosis, even at atypical locations and most patients cope well with the side effects.