Treatment of pituitary neoplasms with temozolomide: a review.


Temozolomide, an orally administered alkylating agent, is used to treat malignant gliomas. Recent reports also have documented its efficacy in the treatment of pituitary adenomas and carcinomas. Temozolomide methylates DNA and thereby exhibits an antitumor effect. O⁶-methylguanine-DNA methyltransferase (MGMT), a DNA repair enzyme, removes alkylating adducts… (More)
DOI: 10.1002/cncr.25413


Cite this paper

@article{Syro2011TreatmentOP, title={Treatment of pituitary neoplasms with temozolomide: a review.}, author={Luis V. Syro and Le{\'o}n Dar{\'i}o Ort{\'i}z and Bernd Walter Scheithauer and Ricardo Vincent Lloyd and Queenie Lau and Ricardo Gonz{\'a}lez and Humberto Uribe and Michael Cusimano and Kalman L Kovacs and {\'E}va Horv{\'a}th}, journal={Cancer}, year={2011}, volume={117 17}, pages={4101-2; author reply 4102} }