Treatment of patients with venous insufficiency with fresh plant horse chestnut seed extract: A review of 5 clinical studies

  title={Treatment of patients with venous insufficiency with fresh plant horse chestnut seed extract: A review of 5 clinical studies},
  author={Andy Suter and Silvia Bommer and Jordan Rechner},
  journal={Advances in Therapy},
Extracts from the seed of the horse chestnut (Aesculus hippocastanum L.) have traditionally been used to treat patients with chronic venous insufficiency and to alleviate its associated symptoms, including lower leg swelling. The efficacy of preparations that contain horse chestnut seed extract (HCSE) is believed to be due largely to an inhibitory effect on the catalytic breakdown of capillary wall proteoglycans. Aesculaforce® is a fresh plant HCSE that is available as an oral tincture, as… 

Which plant for which skin disease? Part 2: Dermatophytes, chronic venous insufficiency, photoprotection, actinic keratoses, vitiligo, hair loss, cosmetic indications

Botanicals with anti‐edema effects in chronic venous insufficiency are discussed and plant extracts from witch hazel, green tea, the fern Polypodium leucotomos and others contain antioxidant polyphenolic compounds that may protect the skin from sunburn and photoaging when administered topically or systemically.

In vitro skin permeation of escin in the new gel formulation of Aesculus hippocastanum (Horse Chestnut)

Owing to its favourable penetration and stability characteristics the new gel formulation could be an  alternative for the treatment of chronic venous insufficiency and inflammatory  soft tissue inflammation.

Anti-inflammatory effects of Aesculus hippocastanum L. tincture and the pro-/antioxidant bodily state of rats with adjuvant arthritis

The results of the study clearly indicate that AH may be beneficial due to its anti-inflammatory and anti-oxidant effects, and may be the promising features for its prospective use as supplementary therapy beside the conventional treatment.

Hypoglycaemic and Hypocholesterolimic Efficacy of Horse Chestnut (Aesculus indica) using Rat Models

An attempt was made to see the hypocholesterolemic and hypoglycaemic efficacy of the flour by running animal trial, and HDL which is good cholesterol, among the test diet, was found maximum 39.41 mg/dl in processed flour (75 per cent) fed rats.

A nutraceutical formulation combined with sclerofoam-assisted laser treatment ameliorates chronic venous insufficiency

A promising approach to the treatment of chronic venous insufficiency is shown that warrants further clinical studies in larger cohorts of patients.

LivRelief varicose veins cream in the treatment of chronic venous insufficiency of the lower limbs: A 6-week single arm pilot study

Preliminary results suggest that the LivRelief Varicose Vein Cream could improve some of the clinical symptoms associated with the presence of varicose veins.

Which plant for which skin disease? Part 1: Atopic dermatitis, psoriasis, acne, condyloma and herpes simplex

Clinical studies with botanicals for atopic dermatitis, psoriasis, acne, condylomata acuminata and herpes simplex are discussed and positive plant monographs with dermatological relevance of the former German Commission E. coli are introduced.

Horse Chestnut (Aesculus Hippocastanum) for Venous Insufficiency

Glycosides and lactone glycosides, including protoaesigenin, barringeogenol-C, {reference 2) hippocaesculin, 6-E-glucoside7-hydroxy coumarin, and others, collectively called aescin are provided.

Drug interactions of natural supplements in dermatology: a review

Clinical use and drug interactions of six natural supplements commonly recommended in dermatology are reviewed, finding an increased risk of myopathy and rhabdomyolysis when nicotinic acid is taken by patients using statins and polypodium leucotomos and turmeric may interfere with the CYP metabolic pathway.

A Unique Natural Remedy that Alleviates Varicose Vein

Chamomile 5 capsules and ointment are newly developed herbal remedies that have been shown to relieve symptoms of varicose veins and Pars Bioscience is pleased to be the first to make these novel remedies commercially available.



Comparative clinical efficacy and tolerability of oxerutins and horse chestnut extract in patients with chronic venous insufficiency.

The maintenance posology of HR is able to stabilize the therapeutic obtained under initial dose conditions, and both compounds exhibit a substantial carry-over effect.

Horse chestnut seed extract for chronic venous insufficiency.

There appeared to be an improvement in CVI related signs and symptoms with HCSE compared with placebo, and the evidence presented implies that HCSE is an efficacious and safe short-term treatment for CVI.

Efficacy, routine effectiveness, and safety of horsechestnut seed extract in the treatment of chronic venous insufficiency. A meta-analysis of randomized controlled trials and large observational studies.

Based on meta-analyses of RCTs and observational studies, HCSE appears to be an effective and safe treatment for CVI.

An Open Study to Assess the Safety and Efficacy of Aesculus hippocastanum Tablets (Aesculaforce® 50 mg) in the Treatment of Chronic Venous Insufficiency

The results of this study indicate that Aesculaforce(r) 50 mg tablets are a safe, well-tolerated and efficacious treatment for Widmer stage I and II CVI.

[Chronic venous insufficiency].

In severe chronic venous insufficiency (CVI) the fascia cruris is increasingly involved in the pathological process, and many pathological changes in the crural ulcer have their anatomical substrate here.

Prevalence of varicose veins and chronic venous insufficiency in men and women in the general population: Edinburgh Vein Study.

In contrast with the findings in most previous studies, mainly conducted in the 1960s and 1970s, chronic venous insufficiency and mild varicose veins were more common in men than women.

Pharmacological properties of saponin fractions obtained from domestic crude drugs : Saponaria officinalis , Primula officinalis and Aesculus hippocastanum

  • Herba Polonica
  • 1976