Treatment of paracetamol (acetaminophen) poisoning with N-acetylcysteine.


Fifteen patients with paracetamol (acetaminophen) poisoning were treated with intravenous N-acetylcystein (300 mg/kg given over 20 h). Mean admission and 4 h plasma-paracetamol concentrations were 262 and 369 microgram/ml, respectively. Liver-function tests remained normal or were only slightly disturbed in 11 of 12 patients treated within 10 h of paracetamol ingestion. Severe liver damage developed in the other patient and in the three in whom treatment was started more than 10 h after paracetamol ingestion. In contrast to cysteamine, N-acetylcysteine was very well tolerated and has the advantage of being available as a pharmaceutical preparation in a 20% sterile solution.

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@article{Prescott1977TreatmentOP, title={Treatment of paracetamol (acetaminophen) poisoning with N-acetylcysteine.}, author={Laurie F Prescott and Jae-seok Park and Andrew Ballantyne and Philippe Adriaenssens and Alex T Proudfoot}, journal={Lancet}, year={1977}, volume={2 8035}, pages={432-4} }