Treatment of oxaliplatin-induced peripheral neuropathy by intravenous mangafodipir.

  title={Treatment of oxaliplatin-induced peripheral neuropathy by intravenous mangafodipir.},
  author={Romain Coriat and J{\'e}r{\^o}me Alexandre and Carole Nicco and Laurent Quinquis and Evelyne Benoit and Christiane Ch{\'e}reau and Herv{\'e} Lemar{\'e}chal and Olivier Mir and Didier Borderie and J M Tr{\'e}luyer and Bernard Weill and Jo{\"e}l Coste and François Goldwasser and Fr{\'e}d{\'e}ric Batteux},
  journal={The Journal of clinical investigation},
  volume={124 1},
BACKGROUND The majority of patients receiving the platinum-based chemotherapy drug oxaliplatin develop peripheral neurotoxicity. Because this neurotoxicity involves ROS production, we investigated the efficacy of mangafodipir, a molecule that has antioxidant properties and is approved for use as an MRI contrast enhancer. METHODS The effects of mangafodipir were examined in mice following treatment with oxaliplatin. Neurotoxicity, axon myelination, and advanced oxidized protein products (AOPPs… CONTINUE READING
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