Treatment of osteoarthritis using a helper-dependent adenoviral vector retargeted to chondrocytes

@inproceedings{Ruan2016TreatmentOO,
  title={Treatment of osteoarthritis using a helper-dependent adenoviral vector retargeted to chondrocytes},
  author={Merry Z. C. Ruan and Vincenzo Cerullo and Racel Cela and Christopher Clarke and Evy Lundgren-Åkerlund and Michael Anthony Barry and Brendan Lee},
  booktitle={Molecular therapy. Methods & clinical development},
  year={2016}
}
Osteoarthritis (OA) is a joint disease characterized by degeneration of the articular cartilage, subchondral bone remodeling, and secondary inflammation. It is among the top three causes of chronic disability, and currently there are no treatment options to prevent disease progression. The localized nature of OA makes it an ideal candidate for gene and cell therapy. However, gene and cell therapy of OA is impeded by inefficient gene transduction of chondrocytes. In this study, we developed a… CONTINUE READING
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