Treatment of oral leukoplakia with a low-dose of beta-carotene and vitamin C supplements: a randomized controlled trial.

@article{Nagao2015TreatmentOO,
  title={Treatment of oral leukoplakia with a low-dose of beta-carotene and vitamin C supplements: a randomized controlled trial.},
  author={Toru Nagao and Saman Warnakulasuriya and Tomoyasu Nakamura and Shinichiro Kato and Keiichi Yamamoto and Hideo Fukano and Kazuya Z. Suzuki and Kazuo Shimozato and Shuji Hashimoto},
  journal={International journal of cancer},
  year={2015},
  volume={136 7},
  pages={
          1708-17
        }
}
Management of oral leukoplakia-a potentially malignant disorder-is currently not evidence-based. Of the few randomized trials that have been reported, most have negative data. Therefore, a multi-centre, randomized, double-blind controlled trial (RCT) was undertaken to evaluate the use of low-dose beta-carotene combined with vitamin C supplements for the treatment and to prevent malignant transformation of oral leukoplakia. 46 Japanese participants with oral leukoplakia were allocated randomly… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 15 CITATIONS

p53 and ki67 as biomarkers in determining response to chemoprevention for oral leukoplakia.

  • Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • 2017
VIEW 4 EXCERPTS
CITES BACKGROUND & METHODS
HIGHLY INFLUENCED

References

Publications referenced by this paper.
SHOWING 1-10 OF 47 REFERENCES

monographs on evaluation of carcinogenic risk to humans, vol

IAR IARC.
  • 100E. Lyon: IARC,
  • 2013
VIEW 1 EXCERPT

monographs on evaluation of carcinogenic risk to humans, vol

IAR IARC.
  • 100E. Lyon: IARC,
  • 2013
VIEW 1 EXCERPT

Factors predicting malignant transformation in oral potentially malignant disorders among patients accrued over a 10-year period in South East England.

  • Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • 2011

B-carotene supplementation and cancer risk: a systematic review and mataanalysis of randomized controlled studies

N Druesne-Pecollo, P Latino-Martel, T Norat
  • Int J Cancer
  • 2010
VIEW 1 EXCERPT

Similar Papers

Loading similar papers…