Treatment of opioid-induced gut dysfunction

@article{Holzer2007TreatmentOO,
  title={Treatment of opioid-induced gut dysfunction},
  author={Peter Holzer},
  journal={Expert Opinion on Investigational Drugs},
  year={2007},
  volume={16},
  pages={181 - 194}
}
  • P. Holzer
  • Published 24 January 2007
  • Medicine, Biology
  • Expert Opinion on Investigational Drugs
Opioid analgesics are the mainstay in the treatment of moderate-to-severe pain, yet their use is frequently associated with adverse effects, the most common and debilitating being constipation. Opioid-induced motor stasis results from blockade of gastrointestinal peristalsis and fluid secretion, and reflects the action of the endogenous opioid system in the gut. Methylnaltrexone and alvimopan are new investigational drugs that selectively target peripheral μ-opioid receptors because they are… 

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  • 2010
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  • Biology, Medicine
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  • 2009

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