Treatment of opioid-induced gut dysfunction
@article{Holzer2007TreatmentOO, title={Treatment of opioid-induced gut dysfunction}, author={Peter Holzer}, journal={Expert Opinion on Investigational Drugs}, year={2007}, volume={16}, pages={181 - 194} }
Opioid analgesics are the mainstay in the treatment of moderate-to-severe pain, yet their use is frequently associated with adverse effects, the most common and debilitating being constipation. Opioid-induced motor stasis results from blockade of gastrointestinal peristalsis and fluid secretion, and reflects the action of the endogenous opioid system in the gut. Methylnaltrexone and alvimopan are new investigational drugs that selectively target peripheral μ-opioid receptors because they are…
98 Citations
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The aim of this article is to review the pathomechanism and possible treatment strategies of OIBD and target opioid receptors in the gut that seem to be the main source of O IBD.
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A step-wise approach to treating OIC should be considered which includes life style modifications, administration of laxatives and stool-softeners, and if necessary, pharmacologic agents to enhance bowel motility and antagonize peripheral μ-opioid receptors.
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It is meaningful that a novel target is provided for handling of OIC in cancer patients receiving chronic opioid therapy and the activation of opioid μ-2 receptors seems associated with OIC induced by opioid analgesics.
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- 2014
As naloxegol is administered orally once daily, has proven efficacious compared to placebo, has an acceptable safety profile, and can be used as add-on to existing pain treatment, it is a welcoming addition to the targeted treatment possibilities for OIBD.
Opioid-Induced Bowel Dysfunction
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- 2013
Multiple agents currently in development show promise in treating OIC without significant impact on analgesia or precipitation of withdrawal symptoms, and the approval and availability of such medications would represent a significant improvement in the management of OIC and OIBD in patients with chronic pain.
Opioid antagonists for prevention and treatment of opioid-induced gastrointestinal effects
- Medicine, BiologyCurrent opinion in anaesthesiology
- 2010
The availability of opioid receptor antagonists with restricted access to the central nervous system provides a novel opportunity to specifically control opioid-induced constipation and other peripheral adverse effects of opioid analgesics.
Opioid-Induced Bowel Dysfunction
- MedicineDrugs
- 2012
Traditional laxatives are normally prescribed but they are often insufficient to alleviate symptoms, especially those from the upper gastrointestinal tract, and new prokinetics, such as prucalopride and lubiprostone, may be more effective in alleviate OIBD.
Methylnaltrexone for the management of unwanted peripheral opioid effects
- Medicine
- 2008
Clinical trials have shown methylnaltrexone to be of benefit in opioid-induced constipation, postoperative ileus and urinary retention, while analgesia remains unabated, and holds great promise in freeing opioid therapy of some of its most-feared adverse aspects.
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