Treatment of opioid-induced gut dysfunction

@article{Holzer2007TreatmentOO,
  title={Treatment of opioid-induced gut dysfunction},
  author={Peter Holzer},
  journal={Expert Opinion on Investigational Drugs},
  year={2007},
  volume={16},
  pages={181 - 194}
}
  • P. Holzer
  • Published 24 January 2007
  • Medicine, Biology
  • Expert Opinion on Investigational Drugs
Opioid analgesics are the mainstay in the treatment of moderate-to-severe pain, yet their use is frequently associated with adverse effects, the most common and debilitating being constipation. Opioid-induced motor stasis results from blockade of gastrointestinal peristalsis and fluid secretion, and reflects the action of the endogenous opioid system in the gut. Methylnaltrexone and alvimopan are new investigational drugs that selectively target peripheral μ-opioid receptors because they are… 
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98 Citations

New approaches to the treatment of opioid-induced constipation.

  • P. Holzer
  • Medicine, Biology
    European review for medical and pharmacological sciences
  • 2008
With this proof of concept, several phase III studies are under way to define optimal dosage, dosing regimen as well as long-term efficacy and safety of methylnaltrexone and alvimopan, and preliminary evidence that these peripherally restricted opioid receptor antagonists may act as prokinetic drugs in their own right.

Novel opioid antagonists for opioid-induced bowel dysfunction and postoperative ileus

The impact of opioid analgesics on the gastrointestinal tract function and the current management possibilities

The aim of this article is to review the pathomechanism and possible treatment strategies of OIBD and target opioid receptors in the gut that seem to be the main source of O IBD.

Treatment of Opioid-induced Constipation: A Therapeutic Update

A step-wise approach to treating OIC should be considered which includes life style modifications, administration of laxatives and stool-softeners, and if necessary, pharmacologic agents to enhance bowel motility and antagonize peripheral μ-opioid receptors.

The Novel Role of Opioid μ-receptors in Gastroenterology

It is meaningful that a novel target is provided for handling of OIC in cancer patients receiving chronic opioid therapy and the activation of opioid μ-2 receptors seems associated with OIC induced by opioid analgesics.

Clinical potential of naloxegol in the management of opioid-induced bowel dysfunction

As naloxegol is administered orally once daily, has proven efficacious compared to placebo, has an acceptable safety profile, and can be used as add-on to existing pain treatment, it is a welcoming addition to the targeted treatment possibilities for OIBD.

Opioid-Induced Bowel Dysfunction

Multiple agents currently in development show promise in treating OIC without significant impact on analgesia or precipitation of withdrawal symptoms, and the approval and availability of such medications would represent a significant improvement in the management of OIC and OIBD in patients with chronic pain.

Opioid antagonists for prevention and treatment of opioid-induced gastrointestinal effects

  • P. Holzer
  • Medicine, Biology
    Current opinion in anaesthesiology
  • 2010
The availability of opioid receptor antagonists with restricted access to the central nervous system provides a novel opportunity to specifically control opioid-induced constipation and other peripheral adverse effects of opioid analgesics.

Opioid receptors in the GI tract: targets for treatment of both diarrhea and constipation in functional bowel disorders?

Opioid receptors in the gastrointestinal tract

  • P. Holzer
  • Biology, Medicine
    Regulatory Peptides
  • 2009
...

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