Treatment of occluded central venous catheters with alteplase: results in 1,064 patients.

@article{Semba2002TreatmentOO,
  title={Treatment of occluded central venous catheters with alteplase: results in 1,064 patients.},
  author={Charles P. Semba and Steven R. Deitcher and Xin Li and Laura Resnansky and Tri Tu and Edward R McCluskey},
  journal={Journal of vascular and interventional radiology : JVIR},
  year={2002},
  volume={13 12},
  pages={1199-205}
}
PURPOSE Thrombosis of central venous access devices (CVADs) is a relatively frequent complication. Alteplase (tissue plasminogen activator) has been used to salvage dysfunctional devices. The purpose of this study was to analyze the safety and efficacy of alteplase after administration of a maximum of two 2-mg/2-mL doses to thrombosed CVADs. MATERIALS AND METHODS A combined analysis was performed of two pivotal prospective phase-III clinical trials (Cardiovascular thrombolytic to Open… CONTINUE READING