Treatment of obese subjects with the oral growth hormone secretagogue MK-677 affects serum concentrations of several lipoproteins, but not lipoprotein(a).

@article{Svensson1999TreatmentOO,
  title={Treatment of obese subjects with the oral growth hormone secretagogue MK-677 affects serum concentrations of several lipoproteins, but not lipoprotein(a).},
  author={Johan Svensson and J O Jansson and Malin Ottosson and Gudmundur Johannsson and Marja Riitta Taskinen and Olov Wiklund and B A Bengtsson},
  journal={The Journal of clinical endocrinology and metabolism},
  year={1999},
  volume={84 6},
  pages={2028-33}
}
Obesity is associated with blunted GH secretion and an unfavorable lipoprotein pattern. The objective of this study was to investigate the effects of treatment with the oral GH secretagogue MK-677 on lipoproteins in otherwise healthy obese males. The study was randomized, double blind, and parallel. Twenty-four obese males, aged 18-50 yr, with body mass index greater than 30 kg/m2 and waist/hip ratio above 0.95 were treated with 25 mg MK-677 (n = 12) or placebo (n = 12) daily for 8 weeks. MK… CONTINUE READING