Treatment of obese diabetic mice with a heme oxygenase inducer reduces visceral and subcutaneous adiposity, increases adiponectin levels, and improves insulin sensitivity and glucose tolerance.

@article{Li2008TreatmentOO,
  title={Treatment of obese diabetic mice with a heme oxygenase inducer reduces visceral and subcutaneous adiposity, increases adiponectin levels, and improves insulin sensitivity and glucose tolerance.},
  author={Ming Li and Dong Hyun Kim and Peter L Tsenovoy and Stephen J Peterson and Rita Rezzani and Luigi Fabrizio Rodella and Wilbert S Aronow and Susumu Ikehara and Nader G Abraham},
  journal={Diabetes},
  year={2008},
  volume={57 6},
  pages={1526-35}
}
OBJECTIVE We hypothesized that the induction of heme oxygenase (HO)-1 and increased HO activity, which induces arterial antioxidative enzymes and vasoprotection in a mouse and a rat model of diabetes, would ameliorate insulin resistance, obesity, and diabetes in the ob mouse model of type 2 diabetes. RESEARCH DESIGN AND METHODS Lean and ob mice were intraperitoneally administered the HO-1 inducer cobalt protoporphyrin (3 mg/kg CoPP) with and without the HO inhibitor stannous mesoporphyrin (2… CONTINUE READING
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I - 4 F treatment reduces adiposity , increases adiponectin levels and improves insulin sensitivity in obese mice

  • RJ Chernick, P Martasek, RD Levere, R Margreiter, NG Abraham
  • J Lipid Res . 19 April
  • 2008

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