Treatment of neuroinflammation by soluble tumor necrosis factor receptor Type II fused to a thermally responsive carrier.

@article{Shamji2008TreatmentON,
  title={Treatment of neuroinflammation by soluble tumor necrosis factor receptor Type II fused to a thermally responsive carrier.},
  author={Mohammed F. Shamji and Liufang Jing and Jun Chen and Priscilla Y. Hwang and Odelia Ghodsizadeh and Allan H. Friedman and William J. Richardson and Lori A. Setton},
  journal={Journal of neurosurgery. Spine},
  year={2008},
  volume={9 2},
  pages={
          221-8
        }
}
OBJECT Biochemical irritation of the dorsal root ganglion (DRG) after intervertebral disc herniation contributes to radiculopathy through tumor necrosis factor-alpha (TNFalpha)-mediated inflammation. Soluble TNF receptor Type II (sTNFRII) sequesters this cytokine, providing clinical benefit. Previous work involving conjugation of sTNFRII with thermally responsive elastin-like polypeptide (ELP) yielded a chimeric protein (ELP-sTNFRII) with in vitro anti-TNFalpha bioactivity. Furthermore… CONTINUE READING

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