Treatment of nephrogenic diabetes insipidus with prostaglandin synthesis inhibitors.

@article{Libber1986TreatmentON,
  title={Treatment of nephrogenic diabetes insipidus with prostaglandin synthesis inhibitors.},
  author={S M Libber and Helen F Harrison and Dennis Spector},
  journal={The Journal of pediatrics},
  year={1986},
  volume={108 2},
  pages={
          305-11
        }
}
The antidiuretic effect of two prostaglandin synthetase inhibitors, ibuprofen (25 mg/kg/day) and indomethacin (2 mg/kg/day), was studied in patients aged 8 to 18 years with hereditary nephrogenic diabetes insipidus. Ibuprofen (studied in five patients) did not have demonstrable effects on urine volume, free water clearance, or osmolar clearance, but fractional excretion of sodium decreased from a mean of 0.38% to 0.19% (P less than 0.05). In contrast, indomethacin (studied in three patients… CONTINUE READING

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