Treatment of negative symptoms: Where do we stand, and where do we go?

@article{Aleman2017TreatmentON,
  title={Treatment of negative symptoms: Where do we stand, and where do we go?},
  author={Andr{\'e} Aleman and Tania M. Lincoln and Richard Bruggeman and Ingrid Melle and Johan Arends and Celso Arango and Henderikus Knegtering},
  journal={Schizophrenia Research},
  year={2017},
  volume={186},
  pages={55-62}
}

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An overview of reviews and meta-analyses of double-blind, controlled randomised trials, in which the efficacy of pharmacological and non-pharmacological interventions for negative symptoms was assessed is presented.

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This review provides a re-evaluation of the theoretical literature on negative symptoms to inform and identify “treatment targets” to reduce them and a review of the empirical literature on cognitive behavior therapy for treating negative symptoms is offered.

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...

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TLDR
In general, the second-generation antipsychotics (SGAs) do not appear to have good efficacy in negative symptoms, although some show better efficacy than first-generation anti-schizophrenia drugs, some of which also demonstrated efficacy innegative symptoms.

Adapted cognitive–behavioural therapy required for targeting negative symptoms in schizophrenia: meta-analysis and meta-regression

TLDR
The co-occurring beneficial effect of conventional CBT on negative symptoms found in older studies was not supported by more recent studies, and it is now necessary to further disentangle effective treatment ingredients of older studies in order to guide the development of future CBT interventions aimed at negative symptom reduction.

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TLDR
The present results indicate that the negative impact of antipsychotics in this regard is overstated; conversely, the present results also indicate that the authors must look beyond antipsychotic treatment in patients with schizophrenia in their efforts to improve motivation.

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TLDR
The results highlight the relevance of self-concepts related to social abilities, dysfunctional beliefs, and global self-worth alone and in interaction with ToM deficits for negative symptoms and thereby provide a helpful basis for advancing psychosocial interventions.
...