Treatment of narcolepsy with codeine.

  title={Treatment of narcolepsy with codeine.},
  author={June M. Fry and Mark R. Pressman and M A DiPhillipo and M Forst-Paulus},
  volume={9 1 Pt 2},
The effectiveness of codeine as a treatment for the excessive daytime sleepiness of narcolepsy was studied in two experimental trials. In an open trial of codeine in five narcoleptic subjects, dramatic clinical improvement was reported. However, all-night polysomnography and maintenance of wakefulness tests before and after codeine showed no significant differences. A double-blind placebo-codeine trial was conducted in which eight narcoleptic subjects received codeine for 1 week and placebo for… CONTINUE READING

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