Treatment of myoclonus with l‐5‐hydroxytryptophan and carbidopa: Clinical, electrophusiological, and biochemical observations

@article{Thal1980TreatmentOM,
  title={Treatment of myoclonus with l‐5‐hydroxytryptophan and carbidopa: Clinical, electrophusiological, and biochemical observations},
  author={Leon Thal and Nansie S. Sharpless and L. Wolfson and Robert Katzman.},
  journal={Annals of Neurology},
  year={1980},
  volume={7}
}
Six patients with myoclonus of varying cause were treated with L‐5‐hydroxytryptophan (L‐5‐HTP) and carbidopa. While spontaneous myoclonus decreased in three of the patients and action myoclonus in four, only two patients had marked functional improvement. Side effects included gastrointestinal and affective disturbances. L‐5‐HTP therapy caused a diminished frequency of paroxysmal discharges in the electroencephalograms of three patients which did not always correlate with clinical improvement… Expand
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The serotonin precursor L-5-hydroxytryptophan is useful therapy for patients with posthypoxic intention myoclonus, but it should be given with caution because it produces a high incidence of side effects. Expand
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TLDR
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