Treatment of myocardial ischemia with bone marrow-derived mesenchymal stem cells overexpressing hepatocyte growth factor.

@article{Duan2003TreatmentOM,
  title={Treatment of myocardial ischemia with bone marrow-derived mesenchymal stem cells overexpressing hepatocyte growth factor.},
  author={Hai-feng Duan and Chu-tse Wu and Dan-Li Wu and Ying Lu and Hong-jun Liu and Xiao-qin Ha and Qun-wei Zhang and Hua Wang and Xiang-xu Jia and Li-Shing Wang},
  journal={Molecular therapy : the journal of the American Society of Gene Therapy},
  year={2003},
  volume={8 3},
  pages={467-74}
}
Mesenchymal stem cells could differentiate into cardiomyocytes in vitro and have been shown to reconstitute the impaired myocardium in vivo. Hepatocyte growth factor, a recognized angiogenic factor and endothelial cell chemoattractant, has been applied in the treatment of myocardial ischemia. In this study, we used a ligation model of proximal left anterior descending coronary artery of rats to evaluate the effect of mesenchymal stem cells overexpressing hepatocyte growth factor in the… CONTINUE READING
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