Treatment of murine peritoneal macrophages with bacterial lipopolysaccharide alters expression of c-fos and c-myc oncogenes.

@article{Introna1986TreatmentOM,
  title={Treatment of murine peritoneal macrophages with bacterial lipopolysaccharide alters expression of c-fos and c-myc oncogenes.},
  author={Martino Introna and Thomas A Hamilton and Russel E. Kaufman and D. O. Adams and Robert C. Bast},
  journal={Journal of immunology},
  year={1986},
  volume={137 8},
  pages={2711-5}
}
Expression of the c-fos, c-myc, and c-fms proto-oncogenes has been studied in thioglycollate-elicited murine peritoneal macrophages after exposure to lipopolysaccharide (LPS). After incubation with LPS (20 ng/ml), a transient and rapid induction of the expression of c-fos and c-myc oncogenes could be observed, whereas the RNA levels for c-fms were not affected. Treatment with lipid A, the active moiety of the LPS molecule, increased the c-fos and c-myc expression to a comparable degree. Similar… CONTINUE READING

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