Treatment of murine Th1- and Th2-mediated inflammatory bowel disease with NF-kappa B decoy oligonucleotides.

@article{FichtnerFeigl2005TreatmentOM,
  title={Treatment of murine Th1- and Th2-mediated inflammatory bowel disease with NF-kappa B decoy oligonucleotides.},
  author={Stefan Fichtner-Feigl and Ivan Fuss and Jan Prei\ss and Warren Strober and Atsushi Kitani},
  journal={The Journal of clinical investigation},
  year={2005},
  volume={115 11},
  pages={3057-71}
}
The Th1 and Th2 T cell responses that underlie inflammatory bowel diseases (IBDs) are likely to depend on NF-kappaB transcriptional activity. We explored this possibility in studies in which we determined the capacity of NF-kappaB decoy oligodeoxynucleotides (decoy ODNs) to treat various murine models of IBD. In initial studies, we showed that i.r. (intrarectal) or i.p. administration of decoy ODNs encapsulated in a viral envelope prevented and treated a model of acute trinitrobenzene sulfonic… CONTINUE READING
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