Treatment of murine B cell lymphoma with bispecific monoclonal antibodies (anti-idiotype x anti-CD3).

@article{Demanet1991TreatmentOM,
  title={Treatment of murine B cell lymphoma with bispecific monoclonal antibodies (anti-idiotype x anti-CD3).},
  author={C Demanet and Jana Brissinck and Monique van Mechelen and Oberdan Leo and Kris 8 Thielemans},
  journal={Journal of immunology},
  year={1991},
  volume={147 3},
  pages={1091-7}
}
It has previously been reported that T lymphocytes can be targeted by using bispecific antibodies consisting of anti-target antibody and anti-CD3. In the present study, a bispecific mAb was developed by somatic hybridization of mouse hybridomas, one producing a mAb against the Id determinant of the mouse B cell lymphoma 38C13 and the other a mAb against a polymorphic determinant on murine CD3. The bispecific antibody, anti-38C13 x anti-CD3, is bi-isotypic (IgG1 x IgG2a) and was purified by ion… CONTINUE READING