Treatment of multifunctional enzymesin metabolic pathway analysis

  title={Treatment of multifunctional enzymesin metabolic pathway analysis},
  author={Ionela Zevedei-Oancea and Stefan Schuster},
  journal={Biophysical chemistry},
  volume={99 1},
In metabolic pathway analysis, it should be considered that many enzymes operate with low specificity (e.g. nucleoside diphosphokinase, uridine kinase, transketolase, aldolase), so that various substrates and products can be converted. Here, we analyze the effect of enzymes with low substrate specificity on the elementary flux modes (pathways). We also study the benefits of two different approaches to describing multifunctional enzymes. The usual description is in terms of (overall) enzymatic… CONTINUE READING