Treatment of mice with naringin alleviates the doxorubicin-induced oxidative stress in the liver of swiss albino mice

  title={Treatment of mice with naringin alleviates the doxorubicin-induced oxidative stress in the liver of swiss albino mice},
  author={Ganesh Ch and R Jagetia and C. Lalrinengi},
  journal={MOJ Anatomy \& Physiology},
Doxorubicin (also known as Adriamycin) is a cytotoxic photosensitive antibiotic, which was isolated from cultures of soil bacteria Streptomyces peucetius var. Caesius [1]. It belongs to anthracycline group of chemicals that include doxorubicin, daunorubicin, epirubicin, and idarubicin. The antracyclines are a class of chemotherapeutic agents which are highly active against numerous malignant disorders. The doxorubicin acts on the neoplastic cells during specific phase of the cell cycle… Expand
Naringin protects rat lung against the doxorubicin-induced biochemical injury
Recent phase I clinical trial has reemphasized the application of doxorubicin in conjunction with lurbinectedin (PM01183) as a useful paradigm in the treatment of patients presenting with small cell lung cancer. Expand
Protection of Doxorubicin-Induced Biochemical Injury in the Rat Bone Marrow by a Dietary Bioflavonoid Naringin
This study shows that naringin attenuated the doxorubicin-induced biochemical stress and may be a useful agent in reducing the toxicity of doxorbicin in patients. Expand
The effects of naringin on different cyclophosphamide-induced organ toxicities in rats: investigation of changes in some metabolic enzyme activities
  • C. Caglayan
  • Medicine, Chemistry
  • Environmental Science and Pollution Research
  • 2019
Investigation of the effect of NG against CYP-induced liver, brain, kidney, heart, and testis toxicities on some metabolic enzyme activities showed that NG regulates abnormal increases and decreases in CYP -induced metabolic enzymes activities in all tissues. Expand
Effects of Rutin and Quercetin on Doxorubicin-Induced Renocardiotoxicity in Male Wistar Rats
| This study aims to assess the preventive effects of rutin and/or quercetin on doxorubicin-induced kidney and heart injuries and oxidative stress in male Wistar rats. The male Wistar rats, injectedExpand
Mitochondria-Targeting Small Molecules Effectively Prevent Cardiotoxicity Induced by Doxorubicin
The evidence showing that mitochondria-targeting small molecules are promising cardioprotective agents against Dox-induced cardiac events is discussed. Expand


The Citrus Flavanone Naringin Enhances Antioxidant Status in the Albino Rat Liver Treated with Doxorubicin
This study demonstrates that naringin has been able to arrest the doxorubicin-induced oxidative stress by raising the antioxidant status and reducing lipid peroxidation. Expand
The Grape Fruit Bioflavonoid Naringin Protects Against the Doxorubicin-Induced Micronuclei Formation in Mouse Bone Marrow
Doxorubicin (DOX) is clinically used in the management of numerous neoplastic disorders however; development of life threatening cardiotoxicity and normal cytotoxicity is a major impediment inExpand
Assessment of the chemo-preventive effects of various plant constituents against doxorubicin-induced toxicity in rats
Doxorubicin (DXR) is a very potent drug with broad spectrum of biological activity, used to treat a wide variety of human malignancies and many solid tumors. The Clinical efficacy of drug in a wideExpand
Ameliorative effect of naringin against doxorubicin-induced acute cardiac toxicity in rats
Results indicated the protective role of NR against Dox-induced cardiac toxicity in rats, indicating that NR can be used in combination with Dox due to its high cardioprotective effect against D ox-induced cardiomyopathy. Expand
Oxidative stress induced in rat liver by anticancer drugs doxorubicin, paclitaxel and docetaxel.
Concurrent administration of DOX and taxane induced enhanced oxidative stress in comparison to single drugs, which suggests their synergistic prooxidant mode of action in liver. Expand
Anthracyclines: Molecular Advances and Pharmacologic Developments in Antitumor Activity and Cardiotoxicity
An overview of issues confirms that anthracyclines remain “evergreen” drugs with broad clinical indications but have still an improvable therapeutic index. Expand
The grapefruit flavanone naringin protects against the radiation-induced genomic instability in the mice bone marrow: a micronucleus study.
It is demonstrated that NIN is able to protect mouse bone marrow cells against the radiation-induced DNA damage and decline in the cell proliferation as observed by a reduction in the micronucleus frequency and an increase in PCE/NCE ratio, respectively, in the NIN-pretreated irradiated group. Expand
Naringin, a citrus flavonone, protects against radiation-induced chromosome damage in mouse bone marrow.
This study demonstrates that naringin can protect mouse bone marrow cells against radiation-induced chromosomal damage and reveals a dose-dependent scavenging of hydroxyl, superoxide and 2,2 equal to or precedes -diphenyl-1-picryl hydrazyl radical. Expand
An Indigenous Plant Bael (Aegle Marmelos (L.) Correa) Extract Protects Against the Doxorubicin-Induced Cardiotoxicity in Mice
It is demonstrated that AME protects mice against the DOX-induced acute and chronic cardiotoxicity without interfering with the antineoplastic activity of DOX. Expand
Anthracycline-induced cardiotoxicity: overview of studies examining the roles of oxidative stress and free cellular iron.
Several lines of evidence suggest that mechanisms other than the traditionally emphasized "ROS and iron" hypothesis are involved in anthracycline-induced cardiotoxicity and that these alternative mechanisms may be better bases for designing approaches to achieve efficient and safe cardioprotection. Expand