Treatment of metastatic adrenal cortical carcinoma with cisplatin and etoposide (VP-16).

Abstract

Two patients with metastatic adrenal cortical carcinoma were treated with cisplatin and etoposide. Both achieved a partial remission after only one cycle. One patient had a "nonfunctioning" tumor that had previously regressed on mitotane whereas the second patient presented with classical Cushing's syndrome. Although the latter patient's urinary 17-ketosteroids normalized while receiving mitotane, the tumor itself failed to regress objectively. Cisplatin plus etoposide appears to be an active combination for the treatment of metastatic adrenal cortical carcinoma.

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@article{Johnson1986TreatmentOM, title={Treatment of metastatic adrenal cortical carcinoma with cisplatin and etoposide (VP-16).}, author={David H. Johnson and F Anthony Greco}, journal={Cancer}, year={1986}, volume={58 10}, pages={2198-202} }