Corpus ID: 8361091

Treatment of mercury and lead poisonings with dimercaptosuccinic acid ( DMSA ) and sodium

  title={Treatment of mercury and lead poisonings with dimercaptosuccinic acid ( DMSA ) and sodium},
  author={Joseph F. Smith},
S Aaseth J., 1995. Treatment of mercury and lead poisonings with dimercaptosuccinic acid (DMSA) and sodium dimmercapto-propanesulfonate (DMPS). AHA., 2001. Chelation therapy. AHA recommendation.. Anderton RM., 2001. ADA statement on dental amalgam. Anon. 1993. Alzheimer's and aluminum: canning the myth. Anon., 2001. Management of the poisoned/overdosed patient. Anuradha B., 1999. Protective role of DL-alpha-lipoic acid against mercury-induced neural lipid peroxidation. Bardin JA., 2000. Case… Expand
Disturbances in Calcium and Zinc Homeostasis During Testicular Damage Induced by Citrus aurantifolia Juice in Wistar Rats.
It was concluded that CAJ induced a destructive effect on testes of rats as evidenced by damaged testiculartissue, reduced gonado-somatic index, azospermia and disruption in testicular electrolyte homeostasis. Expand
Health effects of methylmercury by
This study critically reviews recent data relating to the health effects of methylmercury in man and the attendant dose-response relationships. New data obtained from animal studies are alsoExpand
Age-related effects of lead poisoning on sex hormones in adult male Wistar rats
In ingestion of lead acetate has an age related effect on male sex hormones in older rats, as well as age-related changes on Wistar Rats. Expand
Effects of selenium and vitamin B6 with their combination in lead acetate induced toxicities in long evans rats.
The experiment was performed on 75 long Evans male rats (Rattus norvegicus), weighing about 145 -170 gm, maintained under standard laboratory condition on pellet diet and drinking water ad libitum.Expand
Effect of lead acetate alone and in combination with whole milk (Star ship®) on body growth and liver functions in an experimentally induced lead toxicity in rat
The Effect of lead acetate alone and in combination with whole milk on body weight gain and some biochemical parameters were carried out on a total of 15 (15 days old) male weaning Long- Evans strainExpand


Effects of some thiol chelators on enzymatic activities in blood, liver and kidneys of acute arsenic (III) exposed mice.
Results indicate that DMSA, DMPS and SAM were not toxic to the liver or kidneys of mice and that treatment with DMSA is more effective than DMPS or SAM in protecting mice from acute hepatic or renal toxicity caused by arsenic. Expand
Serum selenium and gluthathione-peroxidase activities and their interaction with toxic metals in dialysis and renal transplantation patients
It can be concluded that the patients receiving hemodialysis are subjected to more toxic elements than the transplantation patients, and dietary selenium supplement may be suggested in renal failure for the detoxification of elements, such as cadmium and mercury. Expand
Maternal-fetal distribution of mercury (203Hg) released from dental amalgam fillings.
Accumulation of amalgam Hg progresses in maternal and fetal tissues to a steady state with advancing gestation and is maintained, and Dental amalgam usage as a tooth restorative material in pregnant women and children should be reconsidered. Expand
Effects of lead on glutathione S-transferase expression in rat kidney: a dose-response study.
The results indicate that renal GST increases occur at lead levels which are environmentally significant, that these changes precede cellular damage, and suggest that GST may serve as a tissue biomarker of lead exposure. Expand
Metabolic methylation is a possible genotoxicity-enhancing process of inorganic arsenics.
Results indicate that metabolic methylation of inorganic arsenics to dimethylarsenics is predominantly involved in the induction of DNA damage. Expand
Effect of chronic cadmium exposure on glutathione S-transferase and glutathione peroxidase activities in rhesus monkey: the role of selenium.
The mechanism by which selenium decreases Cd toxicity in Rhesus monkeys, seems to rely on the protection of the enzyme systems GST and GSH-Px in the four organs, possibly by forming non-toxic cadmium selenide. Expand
Biochemical bases of the pharmacological action of the flavonoid silymarin and of its structural isomer silibinin.
It is suggested that the biochemical effects observed for the flavonoid in experimental models may settle the basis for understanding the pharmacological action of silymarin and silibinin. Expand
Lead induced disorders in hematopoietic and drug metabolizing enzyme system and their protection by ascorbic acid supplementation.
A significant protective action of vitamin C is indicated against toxic effects of lead on heme synthesis and drug metabolism and a marked reduction in blood and liver lead concentration occurred on vitamin C supplementation. Expand
Glutathione status and cadmium neurotoxicity: studies in discrete brain regions of growing rats.
Measurement of regional Cd levels revealed that Cd administration significantly increased the levels in all brain regions except for the hippocampus, which could be the reason for not finding any change in any of the biochemical parameters studied in this region. Expand
[Mercury concentration in the mouth mucosa of patients with amalgam fillings].
A considerable degree of transfer of mercury from the amalgam fillings to the oral mucosa, it had not resulted in any clinically detectable mucosal lesions, and mercury concentrations in patients without metallic fillings of any kind were normal. Expand