Treatment of melasma.

@article{Rendon2006TreatmentOM,
  title={Treatment of melasma.},
  author={Marta I. Rendon and Mark Berneburg and I Arellano and Mauro Picardo},
  journal={Journal of the American Academy of Dermatology},
  year={2006},
  volume={54 5 Suppl 2},
  pages={
          S272-81
        }
}

A Stepwise Approach to Melasma Management and Treatment

TLDR
While a variety of monotherapies, including hydroquinone, retinoids, and kojic and azelaic acids, have been used to treat melasma, the best results appear to be obtained with combination therapy in a program of sun protection and elimination of exogenous estrogens.

Treatment of Melasma With Oral Administration of Tranexamic Acid

TLDR
Oral administration of tranexamic acid (TA) is an effective and safe therapy for the treatment of melasma and is graded into four levels: excellent, good, fair, and poor.

Advances in the Treatment of Melasma: A Review of the Recent Literature

  • K. ArefievB. Hantash
  • Medicine
    Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
  • 2012
TLDR
Although melasma is difficult to treat, novel therapeutic modalities have emerged and further RCT need to be performed to better assess the safety and efficacy of these novel treatment modalities, especially for the long‐term maintenance of melasma.

Comparison between Intralesional Triamcinolone and Kligman's Formula in Treatment of Melasma.

TLDR
In comparison to topical treatments, triamcinolone microinjection is a new, safe and strong therapeutic method for treatment of melasma.

Interventions for melasma.

TLDR
The quality of studies evaluating melasma treatments was generally poor and available treatments inadequate, and high-quality randomised controlled trials on well-defined participants with long-term outcomes to determine the duration of response are needed.

Topical tranexamic acid as a promising treatment for melasma

  • B. EbrahimiF. Naeini
  • Medicine
    Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences
  • 2014
TLDR
This study's results introduce the topical TA as an effective and safe medication for the treatment of melasma in Iranian women.

Evidence-Based Treatment for Melasma: Expert Opinion and a Review

TLDR
A panel of eminent dermatologists was created and their expert opinion was sought to address lacunae in information to arrive at a working algorithm for optimizing outcome in Indian patients, and this algorithm is expected to act as a basis for guiding and refining therapy in the future.
...

References

SHOWING 1-10 OF 50 REFERENCES

Topical isotretinoin for melasma in Thai patients: a vehicle-controlled clinical trial.

TLDR
Daily use of broad spectrum sunscreen has a significant lightening effect on melasma in Thai patients, however, there was no statistically significant difference between the isotretinoin and vehicle-treated group.

A Comparative Study of 20% Azelaic Acid Cream Monotherapy versus a Sequential Therapy in the Treatment of Melasma in Dark-Skinned Patients

TLDR
A sequential therapy of topical potent steroids +20% AZA cream can be considered as another alternative treatment for melasma, which combines the beneficial effects of both besides perhaps increasing the compliance of the patients.

Efficacy and safety of a new triple-combination agent for the treatment of facial melasma.

TLDR
Two 8-week, multicenter, randomized, investigator-blind studies to compare the efficacy and safety of a hydrophilic cream formulation containing tretinoin 0.05%, hydroquinone 4.0%, and fluocinolone acetonide 0.01% demonstrated that significantly more of the patients treated with RA+HQ+FA experienced complete clearing at the end of week 8.

Topical retinoic acid (tretinoin) for melasma in black patients. A vehicle-controlled clinical trial.

TLDR
This controlled study demonstrates that topical 0.1% tretinoin lightens melasma in black patients, with only mild side effects.

Adapalene in the Treatment of Melasma: A Preliminary Report

TLDR
Early results of this study show that the efficacy of adapalene 0.1% gel is comparable to that of tretinoin 0.05% cream in treatment of melasma (predominantly epidermal type) with better patient acceptability and fewer side effects.

The Combination of Glycolic Acid Peels With a Topical Regimen in the Treatment of Melasma in Dark‐Skinned Patients: A Comparative Study

TLDR
This study demonstrates that serial glycolic acid peels provide an additional effect to a topical regimen which is a modification of the time-tested Kligman's regimen for treating melasma in dark-complexioned individuals if used judiciously and under supervision.

Topical tretinoin (retinoic acid) improves melasma. A vehicle‐controlled, clinical trial

TLDR
Topical tretinoin is of benefit in treating other forms of hyperpigmentation, for example liver spots, and its effectiveness in melasma is investigated.

Dermabrasion: A Curative Treatment for Melasma

Abstract. Melasma is fairly common in Asian patients with a dark skin tone. It has long been known for its recalcitrance to any form of treatment. The objective of this article is to propose

Efficacy of glycolic acid peels in the treatment of melasma.

TLDR
Use of 4% hydroquinone and a daily sunscreen is effective in the treatment of melasma; however, the addition of 4 glycolic acid peels did not enhance the hypopigmenting effect of hydroquin one treatment alone.

Double-blind comparison of azelaic acid and hydroquinone in the treatment of melasma.

TLDR
The clinical efficacy of azelaic acid and hydroquinone creams in the treatment of melasma was compared in a randomized, double-blind study with 155 patients of Indo-Malay-Hispanic origin, finding good to excellent overall results.