Treatment of medulloblastoma with procarbazine, hydroxyurea, and reduced radiation doses to whole brain and spine.

@article{Levin1988TreatmentOM,
  title={Treatment of medulloblastoma with procarbazine, hydroxyurea, and reduced radiation doses to whole brain and spine.},
  author={V. A. Levin and Lissette Rodr{\'i}guez and Michael S. B. Edwards and William M. Wara and Hsiu-Chih Liu and Dorcas S. Fulton and Richard L. Davis and Charles Bo Wilson and Pamela Silver},
  journal={Journal of neurosurgery},
  year={1988},
  volume={68 3},
  pages={383-7}
}
Forty-seven patients with medulloblastoma were treated postoperatively with procarbazine, followed by craniospinal radiation therapy in combination with hydroxyurea. The radiation dose to the posterior fossa was 55 Gy; the spinal cord received 25 Gy and the whole brain 25 to 35 Gy (mean 33 Gy). Seventeen tumors recurred. Only one initial recurrence was in the spinal subarachnoid space; 10 (59%) were in the posterior fossa, and four (24%) were supratentorial. The estimated 5-year disease-free… CONTINUE READING

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