Treatment of lymphoma with radiolabeled antibody: elimination of tumor cells lacking target antigen.

@article{Nourigat1990TreatmentOL,
  title={Treatment of lymphoma with radiolabeled antibody: elimination of tumor cells lacking target antigen.},
  author={Cynthia Nourigat and Christopher C. Badger and Irwin D Bernstein},
  journal={Journal of the National Cancer Institute},
  year={1990},
  volume={82 1},
  pages={
          47-50
        }
}
We have previously shown that 131I-labeled monoclonal antibodies against the Thy1.1 differentiation antigen can induce the regression of Thy1.1 antigen-positive (Thy1.1+) AKR/J SL2 T cell lymphoma nodules in AKR/Cum (Thy1.2+) mice. In this study, we examined the ability of 131I-labeled anti-Thy1.1 antibodies to eliminate tumor nodules containing variant lymphoma cells that do not express the Thy1.1 antigen (Thy1.1-). AKR/Cum mice were sc inoculated with mixtures of 1-2 X 10(7) AKR/J SL2 cells… CONTINUE READING

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