Treatment of leprosy/Hansen's disease in the early 21st century
@article{Worobec2009TreatmentOL, title={Treatment of leprosy/Hansen's disease in the early 21st century}, author={Sophie M. Worobec}, journal={Dermatologic Therapy}, year={2009}, volume={22} }
Leprosy, or Hansen's disease (HD), is caused by Mycobacterium leprae, a slowly dividing mycobacterium that has evolved to be an intracellular parasite, causing skin lesions and nerve damage. Less than 5% of people exposed to M. leprae develop clinical disease. Host cell‐mediated resistance determines whether an individual will develop paucibacillary or multibacillary disease. Hansen's disease is a worldwide disease with about 150 new cases reported annually in the United States. Effective anti…
28 Citations
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- 2014
This work has shown that simultaneous occurrence of perianal cutaneous tuberculosis and erythema nodosum leprosum is very rare, even in countries where both mycobacterial infections are endemic.
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The incidence of leprosy in HIV-infected patients under HAART was higher than previously thought and IRIS-leprosy is probably underestimated.
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- Medicine, BiologyInternational journal of dermatology
- 2015
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- Biology, MedicineResearch and reports in tropical medicine
- 2012
Future directions in leprosy treatment will focus on: the molecular signaling mechanism M. leprae uses to avoid triggering an immune response, as well as combating multidrug resistance; vaccine development; development of new diagnostic tests.
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- Medicine
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Clinically, localized lesions with sensory loss in association to local nerve enlargement are most specific, the gold standard for diagnosis is the visualization of M. leprae bacilli on H&E and Fite stains.
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- 2020
It is demonstrated that multibacillary‐multidrug therapy is an efficacious and safe treatment for histoid leprosy and no significant differences were observed between 12 and 24 months of treatment.
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- MedicineRevista brasileira de epidemiologia = Brazilian journal of epidemiology
- 2013
The conclusions that have been reached indicate that the reality of leprosy control with the use of combination drug therapy, still needs to be handled with care, even more so as this is just a fragment of the set of people once under medical attention, which also correspond to a parcel of theSet of people affected by the ailment.
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- Medicine, BiologyThe American Journal of dermatopathology
- 2012
Findings provide support for the existence of additional subtypes of minocycline-induced hyperpigmentation that do not adhere to the classic 3-type model described.
Mycobacterium leprae Is Usually Positive to Periodic Acid-Schiff and Grocott Stains.
- MedicineThe American Journal of dermatopathology
- 2016
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