Treatment of leprosy/Hansen's disease in the early 21st century

@article{Worobec2009TreatmentOL,
  title={Treatment of leprosy/Hansen's disease in the early 21st century},
  author={Sophie M. Worobec},
  journal={Dermatologic Therapy},
  year={2009},
  volume={22}
}
  • S. Worobec
  • Published 1 November 2009
  • Medicine, Biology
  • Dermatologic Therapy
Leprosy, or Hansen's disease (HD), is caused by Mycobacterium leprae, a slowly dividing mycobacterium that has evolved to be an intracellular parasite, causing skin lesions and nerve damage. Less than 5% of people exposed to M. leprae develop clinical disease. Host cell‐mediated resistance determines whether an individual will develop paucibacillary or multibacillary disease. Hansen's disease is a worldwide disease with about 150 new cases reported annually in the United States. Effective anti… 
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Highly Influential Citations
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Methods Citations
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Lepromatous leprosy and perianal tuberculosis: a case report and literature review
TLDR
This work has shown that simultaneous occurrence of perianal cutaneous tuberculosis and erythema nodosum leprosum is very rare, even in countries where both mycobacterial infections are endemic.
Coinfection of leprosy and tuberculosis
TLDR
A 32-year-old female patient who presented with a history of high-grade intermittent fever, cough and painless skin lesions since a month, along with bilateral claw hand is reported, who passed away 3 months after diagnosis of leprosy.
Leprosy and HIV coinfection: a critical approach
TLDR
The incidence of leprosy in HIV-infected patients under HAART was higher than previously thought and IRIS-leprosy is probably underestimated.
Histoid leprosy: review of the literature
  • S. Gupta
  • Medicine, Biology
    International journal of dermatology
  • 2015
TLDR
Though histoid leprosy is a very rare type of leProsy, the higher load of lepra bacilli in these cases makes it a concern as a reservoir for leproSy.
Current approaches and future directions in the treatment of leprosy.
  • S. Worobec
  • Biology, Medicine
    Research and reports in tropical medicine
  • 2012
TLDR
Future directions in leprosy treatment will focus on: the molecular signaling mechanism M. leprae uses to avoid triggering an immune response, as well as combating multidrug resistance; vaccine development; development of new diagnostic tests.
Molluscum-like Lesions in a 12-Year-Old Boy: Answer
TLDR
Clinically, localized lesions with sensory loss in association to local nerve enlargement are most specific, the gold standard for diagnosis is the visualization of M. leprae bacilli on H&E and Fite stains.
Treatment of histoid leprosy: a lack of consensus
TLDR
It is demonstrated that multibacillary‐multidrug therapy is an efficacious and safe treatment for histoid leprosy and no significant differences were observed between 12 and 24 months of treatment.
Realities of leprosy control: updating scenarios.
  • A. Gonçalves
  • Medicine
    Revista brasileira de epidemiologia = Brazilian journal of epidemiology
  • 2013
TLDR
The conclusions that have been reached indicate that the reality of leprosy control with the use of combination drug therapy, still needs to be handled with care, even more so as this is just a fragment of the set of people once under medical attention, which also correspond to a parcel of theSet of people affected by the ailment.
Minocycline-induced hyperpigmentation in multibacillary leprosy.
TLDR
Findings provide support for the existence of additional subtypes of minocycline-induced hyperpigmentation that do not adhere to the classic 3-type model described.
Mycobacterium leprae Is Usually Positive to Periodic Acid-Schiff and Grocott Stains.
TLDR
This case extends the urticarial/dermal hypersensitivity–like changes reported in SSLR from nonbiologic medications to a biologic agent as well.
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