Treatment of intractable hiccups with valproic acid

  title={Treatment of intractable hiccups with valproic acid},
  author={Peter Lars Jacobson and John A. Messenheimer and Thomas W. Farmer},
  pages={1458 - 1458}
we used valproic acid (VPA) to treat five patients with incapacitating, intractable hiccups. Symptoms were eliminated in four and markedly improved in one after other therapies (granulated sugar, carbamazepine, chlorpromazine, and nasopharyngeal stimulation) had failed. Effective peak VPA plasma levels ranged from 34 to 96 pg per milliliter. 
Successful Treatment of Intractable Hiccup with Levetiracetam
A 69‐year old male patient who developed sudden persistent hiccups and was successfully treated with levetiracetam is reported, which should be considered as alternative treatment option in selected patients with intractable hiccup.
Nifedipine for intractable hiccups
Seven patients with intractable hiccups were treated with a calcium channel blocker, nifedipine, and a daily dose of 30 to 60 mg of this drug stopped hiccup in 4 patients and improved them in a 5th patient.
Novel use of amantadine: to treat hiccups.
A complex clinical case of intractable hiccups in a patient with cancer of the pancreas and Parkinson's disease is reported and a potential therapeutic response to a novel agent, amantadine, unlicensed in the treatment of hiccup is discussed.
Systemic review: the pathogenesis and pharmacological treatment of hiccups
Hiccups are familiar to everyone, but remain poorly understood and can be distressing and difficult to treat.
Successful treatment of intractable hiccup with methylphenidate in a lung cancer patient
Methylphenidate (MTP), a mild central nervous system stimulant that is most commonly used for the treatment of attention deficit hyperactivity disorder, was started at a daily dose of 10 mg and was rapidly efficient and well tolerated.
Valproate: an updated review
Valproate in all its aspects is comprehensively surveyed to discuss mechanism of action, clinical pharmacology, clinical efficacy in epilepsy, febrile convulsions and other neurological disorders, side effects, teratogenicity and intoxications.
Psychogenic polydipsia with hyponatremia: report of eleven cases.
  • R. Cronin
  • Medicine
    American journal of kidney diseases : the official journal of the National Kidney Foundation
  • 1987
11 patients with psychogenic polydipsia and hyponatremia (ten men and one woman) who were collectively hospitalized a total of 70 times for treatment of complications of this disorder are described.
Hiccups in terminal disease
  • P. Rousseau
  • Medicine
    The American journal of hospice & palliative care
  • 1994
Although noted frequently in dying patients, the incidence of hiccups in terminally-ill patients is unknown and of limited importance in palliativecare, Kolodzik and Eilers havedefinedhiccups by noting an episode.