Treatment of influenza A (H1N1) virus infections in mice and ferrets with cyanovirin-N.

@article{Smee2008TreatmentOI,
  title={Treatment of influenza A (H1N1) virus infections in mice and ferrets with cyanovirin-N.},
  author={Donald F. Smee and Kevin W. Bailey and M Wong and Barry R O'Keefe and Kirk R Gustafson and Vasiliy P. Mishin and Larisa V. Gubareva},
  journal={Antiviral research},
  year={2008},
  volume={80 3},
  pages={266-71}
}
Cyanovirin-N (CV-N), a protein derived from Nostoc ellipsosporum, neutralizes influenza virus infectivity by binding to specific high-mannose oligosaccharides (oligomannose-8 and -9) at glycosylation sites on the viral hemagglutinin HA1 subunit. Mouse-adapted viruses lose sensitivity to CV-N due to HA1 mutations that eliminate these glycosylation sites. Recently we created a hybrid (reassortant) influenza A/WSN/33 (H1N1) virus containing the HA gene of A/New Caledonia/20/99 (H1N1) with an… CONTINUE READING

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