Treatment of infantile spasms with high-dosage vitamin B6.

  title={Treatment of infantile spasms with high-dosage vitamin B6.},
  author={Joachim Pietz and Ch. Benninger and H. Schaefer and Dan Sontheimer and G Mittermaier and Dietz Rating},
  volume={34 4},
High-dose vitamin B6 (pyridoxine-HCl, 300 mg/kg/day orally) was introduced as the initial treatment of recently manifested infantile spasms in 17 children (13 symptomatic cases with identified brain lesion and 4 cryptogenic cases). 5 of 17 children (2 cryptogenic, 2 with severe pre/perinatal brain damage and one with Sturge-Weber syndrome) were classified as responders to high-dose vitamin B6. In all 5 cases the response to vitamin B6 occurred within the first 2 weeks of treatment and within 4… CONTINUE READING
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