Treatment of idiopathic membranous nephropathy with combination of low-dose tacrolimus and corticosteroids.

@article{He2013TreatmentOI,
  title={Treatment of idiopathic membranous nephropathy with combination of low-dose tacrolimus and corticosteroids.},
  author={Liyu He and Youming Peng and Hong Liu and Yinghong Liu and Shuguang Yuan and F. -Y. Liu and Danyi Yang and Huanhuan Liu and Xian Chen and Jing Shao and Min Fu},
  journal={Journal of nephrology},
  year={2013},
  volume={26 3},
  pages={564-71}
}
BACKGROUND Evidence regarding the optimal dose of tacrolimus (TAC) in treatment of idiopathic membranous nephropathy (IMN) remains inconclusive. The objective of this study was to evaluate the efficacy and safety of low-dose TAC combined with prednisone for patients with IMN. METHODS We conducted a randomized prospective cohort study in IMN patients: 28 patients received oral TAC (target whole blood concentration of 2-4 ng/mL) plus prednisone for 12 months, and 28 patients received prednisone… CONTINUE READING