Treatment of hypoxic–ischemic encephalopathy in mouse by transplantation of embryonic stem cell-derived cells

@article{Ma2007TreatmentOH,
  title={Treatment of hypoxic–ischemic encephalopathy in mouse by transplantation of embryonic stem cell-derived cells},
  author={Jie Ma and Yu Lun Wang and Jianhua Yang and Min Yang and Yoo-hun Suh},
  journal={Neurochemistry International},
  year={2007},
  volume={51},
  pages={57-65}
}
A 7-day-old hypoxic-ischemic encephalopathy (HIE) mouse model was used to study the effect of transplantation of embryonic stem (ES) cell-derived cells on the HIE. After the inducement in vitro, the ES cell-derived cells expressed Nestin and MAP-2, rather than GFAP mRNA. After transplantation, ES cell-derived cells can survive, migrate into the injury site, and specifically differentiate into neurons, showing improvement of the learning ability and memory of the HIE mouse at 8 months post… CONTINUE READING
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