Treatment of hypertension with labetalol in neurosurgical practice

  title={Treatment of hypertension with labetalol in neurosurgical practice},
  author={Christoph Puchstein and Hendrik van Aken and J T Hidding and Ch. Anger and Peter Lawin},
  journal={Acta Neurochirurgica},
SummaryIn neurosurgical patients autoregulation of cerebral perfusion is often lost. Therefore, a sudden increase in blood pressure may lead to an increase in cerebral blood flow cerebral oedema may follow. The influence of labetalol, a new alpha- and beta-adrenoceptor blocking agent, on intracranial pressure and cerebral perfusion pressure was investigated in dogs without and with mass lesions. During hypotension with labetalol the intracranial pressure remained unchanged and the cerebral… CONTINUE READING

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