Treatment of hypertension following endotracheal intubation. A study comparing the efficacy of labetalol, practolol and placebo.

@article{Maharaj1983TreatmentOH,
  title={Treatment of hypertension following endotracheal intubation. A study comparing the efficacy of labetalol, practolol and placebo.},
  author={Rajendra Maharaj and Morrow Thompson and J G Brock-utne and Richard Williamson and John W Downing},
  journal={South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde},
  year={1983},
  volume={63 18},
  pages={
          691-4
        }
}
Labetalol, a new adrenergic receptor antagonist, has both alpha- and beta-blocking properties. Intravenous labetalol (0.25 and 0.5 mg/kg), practolol (0.4 mg/kg) and saline (1 ml), injected prior to anaesthesia, were compared with respect to their effect on the haemodynamic consequences of direct laryngoscopy followed by the passage of an endotracheal tube. When compared with intravenous saline injection, both labetalol and practolol obtunded the tachycardia induced by endotracheal intubation… CONTINUE READING