Treatment of hypertension and renal injury induced by the angiogenesis inhibitor sunitinib: preclinical study.

@article{Lankhorst2014TreatmentOH,
  title={Treatment of hypertension and renal injury induced by the angiogenesis inhibitor sunitinib: preclinical study.},
  author={Stephanie Lankhorst and Mari{\"e}tte H. W. Kappers and Joep H. M. van Esch and Frank M M Smedts and Stefan Sleijfer and Ron H. J. Mathijssen and Hans J. Baelde and A. H. Jan Danser and Anton H. van den Meiracker},
  journal={Hypertension},
  year={2014},
  volume={64 6},
  pages={1282-9}
}
Common adverse effects of angiogenesis inhibition are hypertension and renal injury. To determine the most optimal way to prevent these adverse effects and to explore their interdependency, the following drugs were investigated in unrestrained Wistar Kyoto rats exposed to the angiogenesis inhibitor sunitinib: the dual endothelin receptor antagonist macitentan; the calcium channel blocker amlodipine; the angiotensin-converting enzyme inhibitor captopril; and the phosphodiesterase type 5… CONTINUE READING

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