Treatment of human malignant meningiomas by G207, a replication-competent multimutated herpes simplex virus 1.

@article{Yazaki1995TreatmentOH,
  title={Treatment of human malignant meningiomas by G207, a replication-competent multimutated herpes simplex virus 1.},
  author={Takahito Yazaki and Herbert J. Manz and Samuel David Rabkin and Robert L. Martuza},
  journal={Cancer research},
  year={1995},
  volume={55 21},
  pages={4752-6}
}
We have demonstrated that replication-competent attenuated mutants of herpes simplex virus type 1 (HSV-1) have therapeutic potential for malignant gliomas. Moreover, a recently described multiple mutant HSV (termed G207) has properties which may allow human clinical trials. G207 is able to replicate within and kill cells from three human malignant meningiomas in cell culture. In nude mice harboring s.c. human malignant meningioma (F5), G207 can inhibit growth in a dose-dependent fashion. In… CONTINUE READING

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