Treatment of human cancer cells with selenite or tellurite in combination with auranofin enhances cell death due to redox shift.

@article{Rigobello2009TreatmentOH,
  title={Treatment of human cancer cells with selenite or tellurite in combination with auranofin enhances cell death due to redox shift.},
  author={Maria Pia Rigobello and Valentina Gandin and Alessandra Folda and A K Rundl{\"o}f and Aristi Potamitou Fernandes and Alberto Bindoli and C. M. Asinari di San Marzano and Mikael Bj{\"o}rnstedt},
  journal={Free radical biology & medicine},
  year={2009},
  volume={47 6},
  pages={710-21}
}
Selenium is an essential trace element incorporated as selenocysteine in 25 human selenoproteins. Among them are thioredoxin reductases (TrxR) and glutathione peroxidases, all central proteins in the regulation of the cellular thiol redox state. In this paper the effects of selenite and tellurite treatment in human cancer cells are reported and compared. Our results show that both selenite and tellurite, at relatively low concentrations, are able to increase the expression of mitochondrial and… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 19 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 62 references

Similar Papers

Loading similar papers…