Treatment of high-risk medulloblastoma and other primitive neuroectodermal tumors with reduced dose craniospinal radiation therapy and multi-agent nitrosourea-based chemotherapy.

@article{Prados1996TreatmentOH,
  title={Treatment of high-risk medulloblastoma and other primitive neuroectodermal tumors with reduced dose craniospinal radiation therapy and multi-agent nitrosourea-based chemotherapy.},
  author={Michael D. Prados and William M. Wara and Michael S. B. Edwards and Joann L. Ater and J Rabbit and Kathleen R. Lamborn and Richard L. Davis and V. A. Levin},
  journal={Pediatric neurosurgery},
  year={1996},
  volume={25 4},
  pages={174-81}
}
PURPOSE To investigate toxicity, and progression-free survival (PFS) of children and adults with newly diagnosed medulloblastoma, pineoblastoma, and other primitive neuroectodermal tumors (PNET) with a combined modality regimen of radiation therapy and adjuvant nitrosourea-based chemotherapy. PATIENTS AND METHODS Between 1984 and 1992, 34 evaluable patients with newly diagnosed tumors were treated with chemotherapy and radiotherapy according to a single-arm phase II study. One cycle of… CONTINUE READING
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