Treatment of heterotopic ossification through remote ATP hydrolysis

@article{Peterson2014TreatmentOH,
  title={Treatment of heterotopic ossification through remote ATP hydrolysis},
  author={Jonathan R. Peterson and Sara De La Rosa and Oluwatobi N Eboda and Katherine E. Cilwa and Shailesh Agarwal and Steven R. Buchman and Paul S. Cederna and Chuanwu Xi and Michael D. Morris and DavidN. Herndon and Wenzhong Xiao and Ronald G. Tompkins and Paul H Krebsbach and Stewart C. Wang and Benjamin Levi},
  journal={Science Translational Medicine},
  year={2014},
  volume={6},
  pages={255ra132-255ra132}
}
Heterotopic ossification (HO) is the pathologic development of ectopic bone in soft tissues because of a local or systemic inflammatory insult, such as burn injury or trauma. In HO, mesenchymal stem cells (MSCs) are inappropriately activated to undergo osteogenic differentiation. Through the correlation of in vitro assays and in vivo studies (dorsal scald burn with Achilles tenotomy), we have shown that burn injury enhances the osteogenic potential of MSCs and causes ectopic endochondral… CONTINUE READING
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