Treatment of heredo-degenerative ataxias with amantadine hydrochloride.

  title={Treatment of heredo-degenerative ataxias with amantadine hydrochloride.},
  author={M. I. Botez and Simon N. Young and T. Botez and Omar Pedraza},
  journal={The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques},
  volume={18 3},
Amantadine hydrochloride (AH) was administered (200 mg/day) for more than three months to 17 patients with Friedreich's ataxia (FA) and to 12 patients with olivopontocerebellar atrophies (OPCA) in an open clinical trial. Reaction time (RT) and movement time (MT) with the right and left hand were measured before and after treatment. A striking improvement on both RT and MT was observed in the OPCA group (on seven out of eight measures), whereas in the FA patients improvement was seen only in two… CONTINUE READING