Treatment of hepatitis B e antigen positive chronic hepatitis with telbivudine or adefovir: a randomized trial.

@article{Chan2007TreatmentOH,
  title={Treatment of hepatitis B e antigen positive chronic hepatitis with telbivudine or adefovir: a randomized trial.},
  author={H. Chan and E. J. Heathcote and P. Marcellin and C. Lai and M. Cho and Y. Moon and Y. Chao and R. Myers and G. Minuk and L. Jeffers and W. Sievert and N. Bzowej and G. Harb and R. Kaiser and X. Qiao and N. Brown},
  journal={Annals of internal medicine},
  year={2007},
  volume={147 11},
  pages={
          745-54
        }
}
BACKGROUND The efficacy of nucleoside and nucleotide analogues for hepatitis B has been linked to the magnitude and durability of hepatitis B virus (HBV) suppression. OBJECTIVE To compare the antiviral efficacy of telbivudine and adefovir dipivoxil, and the effects of switching from adefovir to telbivudine, in hepatitis B e antigen (HBeAg)-positive patients with chronic hepatitis B. DESIGN Randomized, controlled, open-label trial. SETTING 16 outpatient clinics. PATIENTS 135 treatment… Expand
206 Citations

Paper Mentions

Observational Clinical Trial
We propose a largely retrospective study with short-term prospective follow-up in a subgroup of patients who have not yet been treated with 48 weeks of entecavir following partial… Expand
ConditionsHepatitis B
InterventionDrug
Interventional Clinical Trial
This research study is being conducted to compare the safety and effectiveness of the investigational medication, LdT (telbivudine) versus adefovir dipivoxil, a drug approved by… Expand
ConditionsChronic Hepatitis B
InterventionDrug
Telbivudine versus lamivudine in patients with chronic hepatitis B.
  • 320
  • PDF
Safety and efficacy of telbivudine for the treatment of chronic hepatitis B
  • M. Osborn
  • Medicine
  • Therapeutics and clinical risk management
  • 2009
  • 11
  • PDF
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 65 REFERENCES
Adefovir dipivoxil for the treatment of hepatitis B e antigen-positive chronic hepatitis B.
  • 1,325
  • PDF
Adefovir dipivoxil for the treatment of hepatitis B e antigen-negative chronic hepatitis B.
  • 981
  • PDF
Effect of switching to tenofovir with emtricitabine in patients with chronic hepatitis B failing to respond to an adefovir-containing regimen
  • 29
A comparison of entecavir and lamivudine for HBeAg-positive chronic hepatitis B.
  • 1,296
  • PDF
Entecavir versus lamivudine for patients with HBeAg-negative chronic hepatitis B.
  • 1,153
  • PDF
Tenofovir for patients with lamivudine‐resistant hepatitis B virus (HBV) infection and high HBV DNA level during adefovir therapy
  • 295
  • PDF
...
1
2
3
4
5
...