Treatment of heart failure with normal ejection fraction: an inconvenient truth!

@article{Paulus2010TreatmentOH,
  title={Treatment of heart failure with normal ejection fraction: an inconvenient truth!},
  author={Walter Paulus and Joris J M van Ballegoij},
  journal={Journal of the American College of Cardiology},
  year={2010},
  volume={55 6},
  pages={526-37}
}
Despite use of similar drugs, outcomes of recent heart failure (HF) trials were frequently neutral in heart failure with normal left ventricular ejection fraction (HFNEF) and positive in heart failure with reduced left ventricular ejection fraction (HFREF). The neutral outcomes of HFNEF trials were often attributed to deficient HFNEF patient recruitment with inclusion of many HFREF or noncardiac patients. Patient recruitment criteria of 21 HFNEF trials were therefore reviewed in reference to… CONTINUE READING
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